3soc: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 3soc is ~~ON HOLD~~

==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin==

~~Authors~~: ~~Chaikuad~~, A., ~~Williams~~, E.~~, Mahajan, P~~., ~~Cooper, C~~.D.O., ~~Sanvitale~~, C.~~, Vollmar, M~~., ~~Muniz, J~~.R.C., ~~Yue, W~~.W.~~, von Delft, F~~., ~~Weigelt, J~~., ~~Arrowsmith, C.H~~., ~~Edwards,~~ A.~~M.,~~ Bountra, C., Bullock, A~~., Structural Genomics Consortium (SGC)~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3soc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOC OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3SOC FirstGlance].

~~Description~~: ~~Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GVD:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE'>GVD</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=3soc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3soc OCA], [https://pdbe.org/3soc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3soc RCSB], [https://www.ebi.ac.uk/pdbsum/3soc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3soc ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Bullock A]]

[[Category: Chaikuad A]]

[[Category: Cooper CDO]]

[[Category: Edwards AM]]

[[Category: Mahajan P]]

[[Category: Muniz JRC]]

[[Category: Sanvitale C]]

[[Category: Vollmar M]]

[[Category: Weigelt J]]

[[Category: Williams E]]

[[Category: Yue WW]]

[[Category: Von Delft F]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3soc is ON HOLD
+==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin==
+<StructureSection load='3soc' size='340' side='right'caption='[[3soc]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-Authors: Chaikuad, A., Williams, E., Mahajan, P., Cooper, C.D.O., Sanvitale, C., Vollmar, M., Muniz, J.R.C., Yue, W.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3soc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SOC FirstGlance]. <br>
-Description: Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GVD:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE'>GVD</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3soc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3soc OCA], [https://pdbe.org/3soc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3soc RCSB], [https://www.ebi.ac.uk/pdbsum/3soc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3soc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arrowsmith CH]]
+[[Category: Bountra C]]
+[[Category: Bullock A]]
+[[Category: Chaikuad A]]
+[[Category: Cooper CDO]]
+[[Category: Edwards AM]]
+[[Category: Mahajan P]]
+[[Category: Muniz JRC]]
+[[Category: Sanvitale C]]
+[[Category: Vollmar M]]
+[[Category: Weigelt J]]
+[[Category: Williams E]]
+[[Category: Yue WW]]
+[[Category: Von Delft F]]