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==Crystal structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) in complex with Phenoxymethyl Benzoic Acid (PMBA)==
==Crystal structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) in complex with Phenoxymethyl Benzoic Acid (PMBA)==
<StructureSection load='3t55' size='340' side='right' caption='[[3t55]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
<StructureSection load='3t55' size='340' side='right'caption='[[3t55]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3t55]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T55 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3t55]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T55 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4RG:3-(PHENOXYMETHYL)BENZOIC+ACID'>4RG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qja|3qja]], [[3t40|3t40]], [[3t44|3t44]], [[3t78|3t78]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4RG:3-(PHENOXYMETHYL)BENZOIC+ACID'>4RG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT1646, MTCY01B2.03, Rv1611, trpC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t55 OCA], [https://pdbe.org/3t55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t55 RCSB], [https://www.ebi.ac.uk/pdbsum/3t55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t55 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indole-3-glycerol-phosphate_synthase Indole-3-glycerol-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.48 4.1.1.48] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t55 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t55 RCSB], [http://www.ebi.ac.uk/pdbsum/3t55 PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/TRPC_MYCTU TRPC_MYCTU]


==See Also==
==See Also==
*[[Indole-3-glycerol phosphate synthase|Indole-3-glycerol phosphate synthase]]
*[[IGPS 3D structures|IGPS 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Indole-3-glycerol-phosphate synthase]]
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Bruning, J B.]]
[[Category: Bruning JB]]
[[Category: Reddy, M C.M.]]
[[Category: Reddy MCM]]
[[Category: Sacchettini, J C.]]
[[Category: Sacchettini JC]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Thurman C]]
[[Category: Thurman, C.]]
[[Category: Structural genomic]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
[[Category: Transferase]]
[[Category: Tryptophan biosynthesis]]

Latest revision as of 13:17, 14 March 2024

Crystal structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) in complex with Phenoxymethyl Benzoic Acid (PMBA)

3t55, resolution 2.06Å

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