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==Crystal structure of S-adenosylmethionine synthetase Rv1392 from Mycobacterium tuberculosis==
==Crystal structure of S-adenosylmethionine synthetase Rv1392 from Mycobacterium tuberculosis==
<StructureSection load='3tde' size='340' side='right' caption='[[3tde]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='3tde' size='340' side='right'caption='[[3tde]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tde]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TDE FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tde]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TDE FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rv2|3rv2]], [[3s82|3s82]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">metK, MT1437, MTCY21B4.09, Rv1392 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tde OCA], [https://pdbe.org/3tde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tde RCSB], [https://www.ebi.ac.uk/pdbsum/3tde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tde ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tde OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tde RCSB], [http://www.ebi.ac.uk/pdbsum/3tde PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/METK_MYCTU METK_MYCTU] Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (By similarity).
 
==See Also==
*[[S-adenosylmethionine synthetase 3D structures|S-adenosylmethionine synthetase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Methionine adenosyltransferase]]
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
[[Category: Adomet]]
[[Category: Sam]]
[[Category: Seattle structural genomics center for infectious disease]]
[[Category: Ssgcid]]
[[Category: Transferase]]
[[Category: Tuberculosis]]

Latest revision as of 13:25, 14 March 2024

Crystal structure of S-adenosylmethionine synthetase Rv1392 from Mycobacterium tuberculosis

3tde, resolution 1.85Å

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