4e71: Difference between revisions
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==Crystal structure of the RHO GTPASE binding domain of Plexin B2== | |||
<StructureSection load='4e71' size='340' side='right'caption='[[4e71]], [[Resolution|resolution]] 2.26Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4e71]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E71 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
[[4e71]] is a 1 chain structure | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e71 OCA], [https://pdbe.org/4e71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e71 RCSB], [https://www.ebi.ac.uk/pdbsum/4e71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e71 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PLXB2_HUMAN PLXB2_HUMAN] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity). | |||
==See Also== | ==See Also== | ||
*[[Plexin|Plexin]] | *[[Plexin 3D structures|Plexin 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Edwards | [[Category: Bountra C]] | ||
[[Category: Guan | [[Category: Edwards AM]] | ||
[[Category: Park | [[Category: Guan X]] | ||
[[Category: Park H]] | |||
[[Category: Tempel | [[Category: Tempel W]] | ||
[[Category: Tong | [[Category: Tong Y]] | ||
[[Category: Wang | [[Category: Wang H]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
Latest revision as of 14:54, 14 March 2024
Crystal structure of the RHO GTPASE binding domain of Plexin B2
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