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{{STRUCTURE_4e82|  PDB=4e82  |  SCENE=  }}
===Crystal structure of monomeric variant of human alpha-defensin 5, HD5 (Glu21EMe mutant)===
{{ABSTRACT_PUBMED_22573326}}


==Function==
==Crystal structure of monomeric variant of human alpha-defensin 5, HD5 (Glu21EMe mutant)==
[[http://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>
<StructureSection load='4e82' size='340' side='right'caption='[[4e82]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4e82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E82 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EME:N-METHYL-L-GLUTAMIC+ACID'>EME</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e82 OCA], [https://pdbe.org/4e82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e82 RCSB], [https://www.ebi.ac.uk/pdbsum/4e82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e82 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>  


==About this Structure==
==See Also==
[[4e82]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E82 OCA].
*[[Defensin 3D structures|Defensin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022573326</ref><references group="xtra"/><references/>
__TOC__
[[Category: Pazgier, M.]]
</StructureSection>
[[Category: Antimicrobial peptide]]
[[Category: Homo sapiens]]
[[Category: Antimicrobial protein]]
[[Category: Large Structures]]
[[Category: Glu21 methylation]]
[[Category: Pazgier M]]
[[Category: Monomeric variant]]
[[Category: Paneth cell]]
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