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{{STRUCTURE_4ec2|  PDB=4ec2  |  SCENE=  }}
===Crystal structure of trimeric frataxin from the yeast Saccharomyces cerevisiae, complexed with ferrous===
{{ABSTRACT_PUBMED_23344952}}


==Function==
==Crystal structure of trimeric frataxin from the yeast Saccharomyces cerevisiae, complexed with ferrous==
[[http://www.uniprot.org/uniprot/FRDA_YEAST FRDA_YEAST]] Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.<ref>PMID:9180083</ref> <ref>PMID:9988680</ref> <ref>PMID:15961414</ref> <ref>PMID:16371422</ref> <ref>PMID:19884169</ref> <ref>PMID:17027502</ref>
<StructureSection load='4ec2' size='340' side='right'caption='[[4ec2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ec2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EC2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.002&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ec2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec2 OCA], [https://pdbe.org/4ec2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ec2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ec2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FRDA_YEAST FRDA_YEAST] Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.<ref>PMID:9180083</ref> <ref>PMID:9988680</ref> <ref>PMID:15961414</ref> <ref>PMID:16371422</ref> <ref>PMID:19884169</ref> <ref>PMID:17027502</ref>  


==About this Structure==
==See Also==
[[4ec2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC2 OCA].
*[[Frataxin 3D Structures|Frataxin 3D Structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:023344952</ref><references group="xtra"/><references/>
__TOC__
[[Category: Ferroxidase]]
</StructureSection>
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Large Structures]]
[[Category: Al-Karadaghi, S.]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Gakh, O.]]
[[Category: Al-Karadaghi S]]
[[Category: Isaya, G.]]
[[Category: Gakh O]]
[[Category: Rajan, S.]]
[[Category: Isaya G]]
[[Category: Soderberg, C A.G.]]
[[Category: Rajan S]]
[[Category: Alpha/beta sandwich]]
[[Category: Soderberg CAG]]
[[Category: Iron-storage]]
[[Category: Metallochaperone]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/4ec2"