4ein: Difference between revisions

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{{STRUCTURE_4ein|  PDB=4ein  |  SCENE=  }}
===Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate===


==Function==
==Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate==
[[http://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity).  
<StructureSection load='4ein' size='340' side='right'caption='[[4ein]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ein]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EIN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOH:2-DEOXY-N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>NOH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ein FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ein OCA], [https://pdbe.org/4ein PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ein RCSB], [https://www.ebi.ac.uk/pdbsum/4ein PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ein ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity).


==About this Structure==
==See Also==
[[4ein]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIN OCA].
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Thymidylate synthase]]
[[Category: Dowiercial A]]
[[Category: Dowiercial, A.]]
[[Category: Jarmula A]]
[[Category: Jarmula, A.]]
[[Category: Kierdaszuk B]]
[[Category: Kierdaszuk, B.]]
[[Category: Rode W]]
[[Category: Rode, W.]]
[[Category: Rypniewski WR]]
[[Category: Rypniewski, W R.]]
[[Category: Wilk P]]
[[Category: Wilk, P.]]
[[Category: Binding site]]
[[Category: Catalysis]]
[[Category: Dimerization]]
[[Category: Methyltransferase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4ein"