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==The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with deoxythymidine.==
==The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with deoxythymidine.==
<StructureSection load='4esh' size='340' side='right' caption='[[4esh]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4esh' size='340' side='right'caption='[[4esh]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4esh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ESH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4esh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ESH FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=THM:THYMIDINE'>THM</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4e5u|4e5u]], [[4edh|4edh]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA2962, Pseudomonas aeruginosa, tmk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4esh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esh OCA], [https://pdbe.org/4esh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4esh RCSB], [https://www.ebi.ac.uk/pdbsum/4esh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4esh ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4esh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4esh RCSB], [http://www.ebi.ac.uk/pdbsum/4esh PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).


==See Also==
==See Also==
*[[Thymidylate kinase|Thymidylate kinase]]
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pseudomonas aeruginosa]]
[[Category: Large Structures]]
[[Category: DTMP kinase]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Jedrzejczak, R.]]
[[Category: Jedrzejczak R]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: Joachimiak, G.]]
[[Category: Joachimiak G]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Sacchettini J]]
[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors.]]
[[Category: Tan K]]
[[Category: Sacchettini, J.]]
[[Category: Tan, K.]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
[[Category: Thymidylate kinase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4esh"