4f7m: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
New page: '''Unreleased structure''' The entry 4f7m is ON HOLD Authors: Liu, J, Zhang, S., Tan, S., Yi, Y., Wu, B., Zhu, F., Wang, H., Qi, J., George, F.G. Description: structural of HLA-A*2402 ...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 4f7m is ON HOLD
==Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009 H1N1 PA (649-658)==
<StructureSection load='4f7m' size='340' side='right'caption='[[4f7m]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4f7m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F7M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f7m OCA], [https://pdbe.org/4f7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f7m RCSB], [https://www.ebi.ac.uk/pdbsum/4f7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f7m ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
== Function ==
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.


Authors: Liu, J, Zhang, S., Tan, S., Yi, Y., Wu, B., Zhu, F., Wang, H., Qi, J., George, F.G.
==See Also==
 
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
Description: structural of HLA-A*2402 complexed with a peptide from influenza A virus
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Influenza A virus H3N2]]
[[Category: Large Structures]]
[[Category: George FG]]
[[Category: Liu J]]
[[Category: Qi J]]
[[Category: Tan S]]
[[Category: Wang H]]
[[Category: Wu B]]
[[Category: Yi Y]]
[[Category: Zhang S]]
[[Category: Zhu F]]
Retrieved from "https://proteopedia.org/4f7m"