1ev8: Difference between revisions

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{{Seed}}
[[Image:1ev8.png|left|200px]]


<!--
==CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI==
The line below this paragraph, containing "STRUCTURE_1ev8", creates the "Structure Box" on the page.
<StructureSection load='1ev8' size='340' side='right'caption='[[1ev8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ev8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EV8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene></td></tr>
{{STRUCTURE_1ev8| PDB=1ev8 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ev8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ev8 OCA], [https://pdbe.org/1ev8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ev8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ev8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ev8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/1ev8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ev8 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI===
==See Also==
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_10841779}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10841779 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10841779}}
 
==About this Structure==
1EV8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EV8 OCA].
 
==Reference==
Catalytic cysteine of thymidylate synthase is activated upon substrate binding., Phan J, Mahdavian E, Nivens MC, Minor W, Berger S, Spencer HT, Dunlap RB, Lebioda L, Biochemistry. 2000 Jun 13;39(23):6969-78. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10841779 10841779]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Thymidylate synthase]]
[[Category: Berger S]]
[[Category: Berger, S.]]
[[Category: Dunlap RB]]
[[Category: Dunlap, R B.]]
[[Category: Lebioda L]]
[[Category: Lebioda, L.]]
[[Category: Mahdavian E]]
[[Category: Mahdavian, E.]]
[[Category: Minor W]]
[[Category: Minor, W.]]
[[Category: Nivens MC]]
[[Category: Nivens, M C.]]
[[Category: Phan J]]
[[Category: Phan, J.]]
[[Category: Spencer HT]]
[[Category: Spencer, H T.]]
[[Category: Cys167 e. coli thymidylate synthase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:04:26 2008''

Latest revision as of 10:06, 20 March 2024

CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI

1ev8, resolution 2.60Å

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