1f95: Difference between revisions

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{{Seed}}
[[Image:1f95.png|left|200px]]


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==SOLUTION STRUCTURE OF DYNEIN LIGHT CHAIN 8 (DLC8) AND BIM PEPTIDE COMPLEX==
The line below this paragraph, containing "STRUCTURE_1f95", creates the "Structure Box" on the page.
<StructureSection load='1f95' size='340' side='right'caption='[[1f95]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1f95]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F95 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f95 OCA], [https://pdbe.org/1f95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f95 RCSB], [https://www.ebi.ac.uk/pdbsum/1f95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f95 ProSAT]</span></td></tr>
{{STRUCTURE_1f95| PDB=1f95 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYL1_RAT DYL1_RAT] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.  Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.  Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (By similarity).  Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/1f95_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f95 ConSurf].
<div style="clear:both"></div>


===SOLUTION STRUCTURE OF DYNEIN LIGHT CHAIN 8 (DLC8) AND BIM PEPTIDE COMPLEX===
==See Also==
 
*[[Dynein 3D structures|Dynein 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_11178896}}, adds the Publication Abstract to the page
[[Category: Homo sapiens]]
(as it appears on PubMed at http://www.pubmed.gov), where 11178896 is the PubMed ID number.
[[Category: Large Structures]]
-->
{{ABSTRACT_PUBMED_11178896}}
 
==About this Structure==
1F95 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F95 OCA].
 
==Reference==
Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain., Fan J, Zhang Q, Tochio H, Li M, Zhang M, J Mol Biol. 2001 Feb 9;306(1):97-108. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11178896 11178896]
[[Category: Protein complex]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Fan, J S.]]
[[Category: Fan J-S]]
[[Category: Li, M.]]
[[Category: Li M]]
[[Category: Tochio, H.]]
[[Category: Tochio H]]
[[Category: Zhang, M.]]
[[Category: Zhang M]]
[[Category: Zhang, Q.]]
[[Category: Zhang Q]]
[[Category: Bim]]
[[Category: Dlc8]]
[[Category: Dynein]]
[[Category: Light chain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:53:48 2008''
Retrieved from "https://proteopedia.org/1f95"