6lzl: Difference between revisions

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~~'''Unreleased structure'''~~

~~The~~ entry ~~6lzl~~ is ~~ON HOLD~~

==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine==

== Structural highlights ==

<table><tr><td colspan='2'>[[6lzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZL OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6LZL FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYR:(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one'>AYR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzl OCA], [https://pdbe.org/6lzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzl RCSB], [https://www.ebi.ac.uk/pdbsum/6lzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzl ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>

== Function ==

[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

~~Authors: Liu, Z.H., Wu, D., Lu, W.Q., Huang, J.~~

==See Also==

*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]

~~Description~~: ~~Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: ~~Lu, W.Q~~]]

__TOC__

[[Category: ~~Wu, D~~]]

</StructureSection>

[[Category: ~~Huang, J~~]]

[[Category: Homo sapiens]]

[[Category: ~~Liu, Z.H~~]]

[[Category: Large Structures]]

[[Category: Huang J]]

[[Category: Liu ZH]]

[[Category: Lu WQ]]

[[Category: Wu D]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6lzl is ON HOLD
+==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine==
+<StructureSection load='6lzl' size='340' side='right'caption='[[6lzl]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6lzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LZL FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYR:(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one'>AYR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzl OCA], [https://pdbe.org/6lzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzl RCSB], [https://www.ebi.ac.uk/pdbsum/6lzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzl ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
-Authors: Liu, Z.H., Wu, D., Lu, W.Q., Huang, J.
+==See Also==
+*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
-Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Lu, W.Q]]
+__TOC__
-[[Category: Wu, D]]
+</StructureSection>
-[[Category: Huang, J]]
+[[Category: Homo sapiens]]
-[[Category: Liu, Z.H]]
+[[Category: Large Structures]]
+[[Category: Huang J]]
+[[Category: Liu ZH]]
+[[Category: Lu WQ]]
+[[Category: Wu D]]