7p3m: Difference between revisions
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New page: '''Unreleased structure''' The entry 7p3m is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Solution structures of HIV-1 and SIVmac p6 and their interaction with accessory proteins Vpr and Vpx in the presence of DPC micelles== | |||
<StructureSection load='7p3m' size='340' side='right'caption='[[7p3m]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7p3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_-_mac_K6W Simian immunodeficiency virus - mac K6W]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P3M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p3m OCA], [https://pdbe.org/7p3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p3m RCSB], [https://www.ebi.ac.uk/pdbsum/7p3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p3m ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GAG_SIVMK GAG_SIVMK] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity). p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Simian immunodeficiency virus - mac K6W]] | |||
[[Category: Bouaziz S]] | |||
[[Category: Wang X]] | |||
Latest revision as of 10:54, 27 March 2024
Solution structures of HIV-1 and SIVmac p6 and their interaction with accessory proteins Vpr and Vpx in the presence of DPC micelles
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