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New page: left|200px<br /><applet load="1fv7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fv7" /> '''A TWO B-Z JUNCTION CONTAINING DNA RESOLVES I...
 
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[[Image:1fv7.gif|left|200px]]<br /><applet load="1fv7" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1fv7" />
'''A TWO B-Z JUNCTION CONTAINING DNA RESOLVES INTO AN ALL RIGHT HANDED DOUBLE HELIX'''<br />


==Overview==
==A TWO B-Z JUNCTION CONTAINING DNA RESOLVES INTO AN ALL RIGHT HANDED DOUBLE HELIX==
Natural and artificial oligonucleotides are capable of assuming many, different conformations and functions. Here we present results of an NMR, restrained molecular modelling study on the conformational preferences of, the modified decanucleotide d((m)C1G2(m)C3G4C5(L)G6(L)(m)C7G8(m)C9G10), .d((m)C11G12(m)C13G14C15(L)G (L)16(m)C17-G18(m)C19G20 ) which contains L, deoxynucleotides in its centre. This chimeric DNA was expected to form a, right-left-right-handed B-type double-helix (BB*B) at low salt, concentration. Actually, it matured into a fully right-handed double helix, with its central C(L)pG(L) core forming a right-handed Z-DNA helix, embedded in a B-DNA matrix (BZ*B). The interplay between base-base and, base-sugar stackings within the core and its immediately adjacent residues, was found to be critical in ensuring the stabilisation of the right-handed, helix. The structure could serve as a model for the design of antisense, oligonucleotides resistant to nucleases and capable of hybridising to, natural DNAs and RNAs.
<StructureSection load='1fv7' size='340' side='right'caption='[[1fv7]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1fv7]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FV7 FirstGlance]. <br>
1FV7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with CH3 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FV7 OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DC:2-DEOXY-L-RIBO-FURANOSYL+CYTOSINE-5-MONOPHOSPHATE'>0DC</scene>, <scene name='pdbligand=0DG:2-DEOXY-L-RIBO-FURANOSYL+GUANINE-5-MONOPHOSPHATE'>0DG</scene>, <scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv7 OCA], [https://pdbe.org/1fv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fv7 RCSB], [https://www.ebi.ac.uk/pdbsum/1fv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fv7 ProSAT]</span></td></tr>
A two B-Z junction containing DNA resolves into an all right-handed double-helix., Mauffret O, El Amri C, Santamaria F, Tevanian G, Rayner B, Fermandjian S, Nucleic Acids Res. 2000 Nov 15;28(22):4403-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11071926 11071926]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Amri, C.El.]]
</StructureSection>
[[Category: Fermandjian, S.]]
[[Category: Large Structures]]
[[Category: Mauffret, O.]]
[[Category: El Amri C]]
[[Category: Rayner, B.]]
[[Category: Fermandjian S]]
[[Category: Santamaria, F.]]
[[Category: Mauffret O]]
[[Category: Tevanian, G]]
[[Category: Rayner B]]
[[Category: CH3]]
[[Category: Santamaria F]]
[[Category: antisense]]
[[Category: Tevanian G]]
[[Category: dna polymorphism]]
[[Category: l enantiomery]]
 
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Latest revision as of 11:16, 27 March 2024

A TWO B-Z JUNCTION CONTAINING DNA RESOLVES INTO AN ALL RIGHT HANDED DOUBLE HELIX

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