2fm2: Difference between revisions

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{{Seed}}
[[Image:2fm2.png|left|200px]]


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==HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211==
The line below this paragraph, containing "STRUCTURE_2fm2", creates the "Structure Box" on the page.
<StructureSection load='2fm2' size='340' side='right'caption='[[2fm2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2fm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FM2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BC:TERT-BUTYL+[(1S)-1-({(1R,2S,5S)-2-[(3S,10S)-3-(CYCLOPROPYLMETHYL)-12-METHYL-4,5,8,11-TETRAOXO-10-PHENYL-2,6,9,12-TETRAAZATRIDECAN-1+-OYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEX-3-YL}CARBONYL)-2,2-DIMETHYLPROPYL]CARBAMATE'>3BC</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2fm2|  PDB=2fm2  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm2 OCA], [https://pdbe.org/2fm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fm2 RCSB], [https://www.ebi.ac.uk/pdbsum/2fm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fm2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9ELS8_9HEPC Q9ELS8_9HEPC]


===HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211===
==See Also==
 
*[[Helicase 3D structures|Helicase 3D structures]]
 
*[[Virus protease 3D structures|Virus protease 3D structures]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16352601}}, adds the Publication Abstract to the page
</StructureSection>
(as it appears on PubMed at http://www.pubmed.gov), where 16352601 is the PubMed ID number.
[[Category: Hepacivirus C]]
-->
[[Category: Hepatitis C virus genotype 1a]]
{{ABSTRACT_PUBMED_16352601}}
[[Category: Large Structures]]
 
[[Category: Bogen SL]]
==About this Structure==
[[Category: Bourne N]]
2FM2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM2 OCA].
[[Category: Chase R]]
 
[[Category: Chen T]]
==Reference==
[[Category: Lemon SM]]
Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations., Yi M, Tong X, Skelton A, Chase R, Chen T, Prongay A, Bogen SL, Saksena AK, Njoroge FG, Veselenak RL, Pyles RB, Bourne N, Malcolm BA, Lemon SM, J Biol Chem. 2006 Mar 24;281(12):8205-15. Epub 2005 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16352601 16352601]
[[Category: Malcolm BA]]
[[Category: Hepatitis c virus]]
[[Category: Njoroge FG]]
[[Category: Single protein]]
[[Category: Prongay A]]
[[Category: Bogen, S L.]]
[[Category: Pyles RB]]
[[Category: Bourne, N.]]
[[Category: Saksena AK]]
[[Category: Chase, R.]]
[[Category: Skelton A]]
[[Category: Chen, T.]]
[[Category: Tong X]]
[[Category: Lemon, S M.]]
[[Category: Veselenak RL]]
[[Category: Malcolm, B A.]]
[[Category: Yi M]]
[[Category: Njoroge, F G.]]
[[Category: Prongay, A.]]
[[Category: Pyles, R B.]]
[[Category: Saksena, A K.]]
[[Category: Skelton, A.]]
[[Category: Tong, X.]]
[[Category: Veselenak, R L.]]
[[Category: Yi, M.]]
[[Category: Hcv]]
[[Category: Hepatitis c virus]]
[[Category: Ketoamide inhibitor]]
[[Category: Ns3/4a protease]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:19:45 2008''
Retrieved from "https://proteopedia.org/2fm2"