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[[Image:1jce.gif|left|200px]]


{{Structure
==MREB FROM THERMOTOGA MARITIMA==
|PDB= 1jce |SIZE=350|CAPTION= <scene name='initialview01'>1jce</scene>, resolution 2.1&Aring;
<StructureSection load='1jce' size='340' side='right'caption='[[1jce]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
<table><tr><td colspan='2'>[[1jce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JCE FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= TM0588 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jce OCA], [https://pdbe.org/1jce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jce RCSB], [https://www.ebi.ac.uk/pdbsum/1jce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jce ProSAT]</span></td></tr>
|RELATEDENTRY=[[1jcf|1JCF]], [[1jcg|1JCG]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jce OCA], [http://www.ebi.ac.uk/pdbsum/1jce PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jce RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q9WZ57_THEMA Q9WZ57_THEMA]
 
== Evolutionary Conservation ==
'''MREB FROM THERMOTOGA MARITIMA'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/1jce_consurf.spt"</scriptWhenChecked>
It was thought until recently that bacteria lack the actin or tubulin filament networks that organize eukaryotic cytoplasm. However, we show here that the bacterial MreB protein assembles into filaments with a subunit repeat similar to that of F-actin-the physiological polymer of eukaryotic actin. By elucidating the MreB crystal structure we demonstrate that MreB and actin are very similar in three dimensions. Moreover, the crystals contain protofilaments, allowing visualization of actin-like strands at atomic resolution. The structure of the MreB protofilament is in remarkably good agreement with the model for F-actin, showing that the proteins assemble in identical orientations. The actin-like properties of MreB explain the finding that MreB forms large fibrous spirals under the cell membrane of rod-shaped cells, where they are involved in cell-shape determination. Thus, prokaryotes are now known to possess homologues both of tubulin, namely FtsZ, and of actin.
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1JCE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JCE OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jce ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Prokaryotic origin of the actin cytoskeleton., van den Ent F, Amos LA, Lowe J, Nature. 2001 Sep 6;413(6851):39-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11544518 11544518]
</StructureSection>
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Amos, L A.]]
[[Category: Amos LA]]
[[Category: Ent, F van den.]]
[[Category: Lowe J]]
[[Category: Lowe, J.]]
[[Category: Van den Ent F]]
[[Category: actin]]
[[Category: ftsz]]
[[Category: hsp-70]]
[[Category: mbl]]
[[Category: mreb]]
[[Category: rod-shape determining]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:31:40 2008''

Latest revision as of 07:50, 3 April 2024

MREB FROM THERMOTOGA MARITIMA

1jce, resolution 2.10Å

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