1ll8: Difference between revisions

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{{Seed}}
[[Image:1ll8.png|left|200px]]


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==Structure and interactions of PAS kinase N-terminal PAS domain: Model for intramolecular kinase regulation==
The line below this paragraph, containing "STRUCTURE_1ll8", creates the "Structure Box" on the page.
<StructureSection load='1ll8' size='340' side='right'caption='[[1ll8]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ll8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LL8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ll8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll8 OCA], [https://pdbe.org/1ll8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ll8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ll8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ll8 ProSAT]</span></td></tr>
{{STRUCTURE_1ll8|  PDB=1ll8  |  SCENE=  }}
</table>
 
== Function ==
===Structure and interactions of PAS kinase N-terminal PAS domain: Model for intramolecular kinase regulation===
[https://www.uniprot.org/uniprot/PASK_HUMAN PASK_HUMAN] Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.<ref>PMID:16275910</ref> <ref>PMID:17052199</ref> <ref>PMID:17595531</ref> <ref>PMID:21181396</ref> <ref>PMID:21418524</ref> <ref>PMID:20943661</ref>  
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_12377121}}, adds the Publication Abstract to the page
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ll/1ll8_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12377121}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ll8 ConSurf].
1LL8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL8 OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:12377121</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Amezcua, C A.]]
[[Category: Amezcua CA]]
[[Category: Gardner, K H.]]
[[Category: Gardner KH]]
[[Category: Harper, S M.]]
[[Category: Harper SM]]
[[Category: Rutter, J.]]
[[Category: Rutter J]]
[[Category: Kinase regulation]]
[[Category: Ligand binding]]
[[Category: Ligand screening]]
[[Category: Pas domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:31:15 2009''
Retrieved from "https://proteopedia.org/1ll8"