2bc8: Difference between revisions

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{{STRUCTURE_2bc8|  PDB=2bc8  |  SCENE=  }}
===[Sec2,3,8,12]-ImI===
{{ABSTRACT_PUBMED_16500898}}


==Function==
==[Sec2,3,8,12]-ImI==
[[http://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref>
<StructureSection load='2bc8' size='340' side='right'caption='[[2bc8]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2bc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BC8 FirstGlance]. <br>
[[2bc8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC8 OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc8 OCA], [https://pdbe.org/2bc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bc8 RCSB], [https://www.ebi.ac.uk/pdbsum/2bc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bc8 ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:016500898</ref><references group="xtra"/><references/>
== Function ==
[[Category: Armishaw, C J.]]
[https://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref>  
[[Category: Conotoxin]]
== References ==
[[Category: Diselenide bond]]
<references/>
[[Category: Disulfide bond]]
__TOC__
[[Category: Helix]]
</StructureSection>
[[Category: Toxin]]
[[Category: Conus imperialis]]
[[Category: Large Structures]]
[[Category: Armishaw CJ]]

Latest revision as of 06:37, 1 May 2024

[Sec2,3,8,12]-ImI

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