2jwe: Difference between revisions

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[[Image:2jwe.gif|left|200px]]


<!--
==Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping==
The line below this paragraph, containing "STRUCTURE_2jwe", creates the "Structure Box" on the page.
<StructureSection load='2jwe' size='340' side='right'caption='[[2jwe]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWE FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwe OCA], [https://pdbe.org/2jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwe RCSB], [https://www.ebi.ac.uk/pdbsum/2jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwe ProSAT]</span></td></tr>
{{STRUCTURE_2jwe|  PDB=2jwe  |  SCENE= }}
</table>
 
== Function ==
'''Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping'''
[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2JWE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWE OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/2jwe_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jwe ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Ji, P.]]
[[Category: Ji P]]
[[Category: Shi, Y Y.]]
[[Category: Shi YY]]
[[Category: Wu, J H.]]
[[Category: Wu JH]]
[[Category: Wu, J W.]]
[[Category: Wu JW]]
[[Category: Yang, Y S.]]
[[Category: Yang YS]]
[[Category: Zhang, J H.]]
[[Category: Zhang JH]]
[[Category: Alternative splicing]]
[[Category: Cell adhesion]]
[[Category: Cell junction]]
[[Category: Dimer]]
[[Category: Domain swapping]]
[[Category: Membrane]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Sh3 domain]]
[[Category: Tight junction]]
[[Category: Tjp1]]
[[Category: Zo-1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:21:01 2008''
Retrieved from "https://proteopedia.org/2jwe"