2kg7: Difference between revisions

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'''Unreleased structure'''


The entry 2kg7 is ON HOLD  until Paper Publication
==Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288==
 
<StructureSection load='2kg7' size='340' side='right'caption='[[2kg7]]' scene=''>
Authors: Ilghari, D., Kirsty, L.L., Waters, L.C., Veverka, V.L., Philip, R.S., Carr, M.D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2kg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG7 FirstGlance]. <br>
Description: Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg7 OCA], [https://pdbe.org/2kg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg7 ProSAT]</span></td></tr>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep  3 15:13:10 2009''
</table>
== Function ==
[https://www.uniprot.org/uniprot/ESXG_MYCTU ESXG_MYCTU] EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol.<ref>PMID:24204276</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kg7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kg7 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Carr MD]]
[[Category: Ilghari D]]
[[Category: Kirsty LL]]
[[Category: Philip RS]]
[[Category: Veverka VL]]
[[Category: Waters LC]]
Retrieved from "https://proteopedia.org/2kg7"