2kv2: Difference between revisions

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{{Seed}}
[[Image:2kv2.jpg|left|200px]]


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==Solution Structure of the human BLM HRDC domain==
The line below this paragraph, containing "STRUCTURE_2kv2", creates the "Structure Box" on the page.
<StructureSection load='2kv2' size='340' side='right'caption='[[2kv2]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KV2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv2 OCA], [https://pdbe.org/2kv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kv2 RCSB], [https://www.ebi.ac.uk/pdbsum/2kv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kv2 ProSAT]</span></td></tr>
{{STRUCTURE_2kv2|  PDB=2kv2  |  SCENE=  }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref>  


===Solution Structure of the human BLM HRDC domain===
==See Also==
 
*[[Helicase 3D structures|Helicase 3D structures]]
 
== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 20639533 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20639533}}
 
==About this Structure==
2KV2 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV2 OCA].
 
==Reference==
<ref group="xtra">PMID:20639533</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Choi, B S.]]
[[Category: Large Structures]]
[[Category: Kim, Y M.]]
[[Category: Choi B-S]]
[[Category: Bloom syndrome]]
[[Category: Kim YM]]
[[Category: Disease mutation]]
[[Category: Dna replication]]
[[Category: Dna-binding]]
[[Category: Gene regulation]]
[[Category: Hrdc domain]]
[[Category: Nucleotide-binding]]
[[Category: Nucleus]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:38:17 2010''
Retrieved from "https://proteopedia.org/2kv2"