2kxp: Difference between revisions
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==Solution NMR structure of V-1 bound to capping protein (CP)== | |||
<StructureSection load='2kxp' size='340' side='right'caption='[[2kxp]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2kxp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxp OCA], [https://pdbe.org/2kxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxp RCSB], [https://www.ebi.ac.uk/pdbsum/2kxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxp ProSAT]</span></td></tr> | |||
== | </table> | ||
[[2kxp]] is a 3 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/CAZA1_CHICK CAZA1_CHICK] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/2kxp_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kxp ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[F-actin capping protein|F-actin capping protein]] | *[[F-actin capping protein|F-actin capping protein]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Fujiwara | [[Category: Fujiwara I]] | ||
[[Category: III | [[Category: Hammer III JA]] | ||
[[Category: Tjandra | [[Category: Tjandra N]] | ||
[[Category: Zwolak | [[Category: Zwolak A]] | ||
Latest revision as of 06:50, 1 May 2024
Solution NMR structure of V-1 bound to capping protein (CP)
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