2l14: Difference between revisions

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{{Seed}}
[[Image:2l14.jpg|left|200px]]


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==Structure of CBP nuclear coactivator binding domain in complex with p53 TAD==
The line below this paragraph, containing "STRUCTURE_2l14", creates the "Structure Box" on the page.
<StructureSection load='2l14' size='340' side='right'caption='[[2l14]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2l14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L14 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l14 OCA], [https://pdbe.org/2l14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l14 RCSB], [https://www.ebi.ac.uk/pdbsum/2l14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l14 ProSAT]</span></td></tr>
{{STRUCTURE_2l14|  PDB=2l14  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref>  


===Structure of CBP nuclear coactivator binding domain in complex with p53 TAD===
==See Also==
 
*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
 
*[[P53 3D structures|P53 3D structures]]
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== References ==
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<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 20961098 is the PubMed ID number.
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</StructureSection>
{{ABSTRACT_PUBMED_20961098}}
 
==About this Structure==
2L14 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L14 OCA].
 
==Reference==
<ref group="xtra">PMID:20961098</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Dyson, H J.]]
[[Category: Dyson HJ]]
[[Category: Lee, C.]]
[[Category: Lee C]]
[[Category: Martinez-Yamout, M A.]]
[[Category: Martinez-Yamout MA]]
[[Category: Wright, P E.]]
[[Category: Wright PE]]
[[Category: Cbp]]
[[Category: P300]]
[[Category: P53]]
[[Category: Protein binding]]
[[Category: Tad]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:04:53 2010''
Retrieved from "https://proteopedia.org/2l14"