2l4i: Difference between revisions

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[[Image:2l4i.png|left|200px]]


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==The Solution Structure of Magnesium bound CIB1==
The line below this paragraph, containing "STRUCTURE_2l4i", creates the "Structure Box" on the page.
<StructureSection load='2l4i' size='340' side='right'caption='[[2l4i]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2l4i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4I FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_2l4i|  PDB=2l4i  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4i OCA], [https://pdbe.org/2l4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4i RCSB], [https://www.ebi.ac.uk/pdbsum/2l4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4i ProSAT]</span></td></tr>
 
</table>
===The Solution Structure of Magnesium bound CIB1===
== Function ==
 
[https://www.uniprot.org/uniprot/CIB1_HUMAN CIB1_HUMAN] May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.<ref>PMID:12714504</ref> <ref>PMID:12881299</ref> <ref>PMID:15685448</ref> <ref>PMID:18627437</ref> <ref>PMID:19805025</ref> <ref>PMID:21264284</ref>
 
== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 21388953 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21388953}}
 
==About this Structure==
[[2l4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4I OCA].  
 
==Reference==
<ref group="xtra">PMID:21388953</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Huang, H.]]
[[Category: Large Structures]]
[[Category: Vogel, H J.]]
[[Category: Huang H]]
[[Category: Vogel HJ]]
Retrieved from "https://proteopedia.org/2l4i"