2lez: Difference between revisions
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== | ==Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a== | ||
[[http://www.uniprot.org/uniprot/PIPB2_SALTY PIPB2_SALTY | <StructureSection load='2lez' size='340' side='right'caption='[[2lez]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2lez]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LEZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lez OCA], [https://pdbe.org/2lez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lez RCSB], [https://www.ebi.ac.uk/pdbsum/2lez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lez ProSAT]</span></td></tr> | |||
== | </table> | ||
<references | == Function == | ||
[[Category: Salmonella enterica subsp. enterica serovar | [https://www.uniprot.org/uniprot/PIPB2_SALTY PIPB2_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in phagocytic cells.<ref>PMID:12864852</ref> <ref>PMID:15987736</ref> <ref>PMID:16938850</ref> | ||
[[Category: Arrowsmith | == References == | ||
[[Category: Daniels | <references/> | ||
[[Category: Garcia | __TOC__ | ||
[[Category: Houliston | </StructureSection> | ||
[[Category: Lemak | [[Category: Large Structures]] | ||
[[Category: Montelione | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | ||
[[Category: Arrowsmith C]] | |||
[[Category: Savchenko | [[Category: Daniels C]] | ||
[[Category: Yee | [[Category: Garcia M]] | ||
[[Category: Houliston S]] | |||
[[Category: Lemak A]] | |||
[[Category: Montelione GT]] | |||
[[Category: Savchenko A]] | |||
[[Category: Yee A]] | |||
Latest revision as of 06:55, 1 May 2024
Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a
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