2lf1: Difference between revisions

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[[Image:2lf1.png|left|200px]]


{{STRUCTURE_2lf1|  PDB=2lf1  |  SCENE=  }}
==Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures==
 
<StructureSection load='2lf1' size='340' side='right'caption='[[2lf1]]' scene=''>
===Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2lf1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LF1 FirstGlance]. <br>
{{ABSTRACT_PUBMED_21410224}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf1 OCA], [https://pdbe.org/2lf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lf1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf1 ProSAT]</span></td></tr>
[[2lf1]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF1 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_LACCA DYR_LACCA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


==See Also==
==See Also==
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021410224</ref><references group="xtra"/>
[[Category: Lacticaseibacillus casei]]
[[Category: Dihydrofolate reductase]]
[[Category: Large Structures]]
[[Category: Lactobacillus casei]]
[[Category: Birdsall B]]
[[Category: Birdsall, B.]]
[[Category: Feeney J]]
[[Category: Feeney, J.]]
[[Category: Kovalevskaya N]]
[[Category: Kovalevskaya, N.]]
[[Category: Polshakov V]]
[[Category: Polshakov, V.]]
[[Category: Dhfr]]
[[Category: Oxidoreductase]]
[[Category: Positive cooperativity]]
[[Category: Protein-ligand interaction]]

Latest revision as of 06:55, 1 May 2024

Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures

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