2ly4: Difference between revisions

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[[Image:2ly4.png|left|200px]]


{{STRUCTURE_2ly4| PDB=2ly4 |  SCENE= }}
==HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail==
<StructureSection load='2ly4' size='340' side='right'caption='[[2ly4]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ly4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LY4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ly4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ly4 OCA], [https://pdbe.org/2ly4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ly4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ly4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ly4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HMGB1_HUMAN HMGB1_HUMAN] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).


===HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail===
==See Also==
 
*[[High mobility group protein|High mobility group protein]]
{{ABSTRACT_PUBMED_23063560}}
__TOC__
 
</StructureSection>
==About this Structure==
[[2ly4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LY4 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Rowell, J P.]]
[[Category: Large Structures]]
[[Category: Simpson, K L.]]
[[Category: Rowell JP]]
[[Category: Stott, K.]]
[[Category: Simpson KL]]
[[Category: Thomas, J O.]]
[[Category: Stott K]]
[[Category: Watson, M.]]
[[Category: Thomas JO]]
[[Category: Hmg]]
[[Category: Watson M]]
[[Category: Nuclear protein-antitumour protein complex]]
[[Category: P53]]
[[Category: Tad]]
Retrieved from "https://proteopedia.org/2ly4"