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==Ligase 10C==
==Ligase 10C==
<StructureSection load='2lze' size='340' side='right'caption='[[2lze]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2lze' size='340' side='right'caption='[[2lze]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2lze]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LZE FirstGlance]. <br>
<table><tr><td colspan='2'>[[2lze]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LZE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lze OCA], [http://pdbe.org/2lze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lze RCSB], [http://www.ebi.ac.uk/pdbsum/2lze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lze ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lze OCA], [https://pdbe.org/2lze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lze RCSB], [https://www.ebi.ac.uk/pdbsum/2lze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lze ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Engineering functional protein scaffolds capable of carrying out chemical catalysis is a major challenge in enzyme design. Starting from a noncatalytic protein scaffold, we recently generated a new RNA ligase by in vitro directed evolution. This artificial enzyme lost its original fold and adopted an entirely new structure with substantially enhanced conformational dynamics, demonstrating that a primordial fold with suitable flexibility is sufficient to carry out enzymatic function.
Structure and dynamics of a primordial catalytic fold generated by in vitro evolution.,Chao FA, Morelli A, Iii JC, Churchfield L, Hagmann LN, Shi L, Masterson LR, Sarangi R, Veglia G, Seelig B Nat Chem Biol. 2012 Dec 9. doi: 10.1038/nchembio.1138. PMID:23222886<ref>PMID:23222886</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2lze" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Synthetic construct sequences]]
[[Category: Synthetic construct]]
[[Category: Chao, F]]
[[Category: Chao F]]
[[Category: Churchfield, L]]
[[Category: Churchfield L]]
[[Category: Hagmann, L]]
[[Category: Hagmann L]]
[[Category: Haugner, J]]
[[Category: Haugner J]]
[[Category: Masterson, L]]
[[Category: Masterson L]]
[[Category: Morelli, A]]
[[Category: Morelli A]]
[[Category: Sarangi, R]]
[[Category: Sarangi R]]
[[Category: Seelig, B]]
[[Category: Seelig B]]
[[Category: Shi, L]]
[[Category: Shi L]]
[[Category: Veglia, G]]
[[Category: Veglia G]]
[[Category: De novo protein]]
[[Category: Ligase]]
Retrieved from "https://proteopedia.org/2lze"