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==Circular Permutant of the WW Domain with Loop 1 Excised==
==Circular Permutant of the WW Domain with Loop 1 Excised==
<StructureSection load='2mdu' size='340' side='right'caption='[[2mdu]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''>
<StructureSection load='2mdu' size='340' side='right'caption='[[2mdu]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mdu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MDU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mdu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDU FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pin|1pin]], [[2kcf|2kcf]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2mdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mdu OCA], [http://pdbe.org/2mdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mdu RCSB], [http://www.ebi.ac.uk/pdbsum/2mdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mdu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mdu OCA], [https://pdbe.org/2mdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mdu RCSB], [https://www.ebi.ac.uk/pdbsum/2mdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mdu ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A hyperstable Pin1 WW domain has been circularly permuted via excision of the fold-nucleating turn; it still folds to form the native three-strand sheet and hydrophobic core features. Multiprobe folding dynamics studies of the normal and circularly permuted sequences, as well as their constituent hairpin fragments and comparable-length beta-strand-loop-beta-strand models, indicate 2-state folding for all topologies. N-terminal hairpin formation is the fold nucleating event for the wild-type sequence; the slower folding circular permutant has a more distributed folding transition state.
Circular Permutation of a WW Domain: Folding Still Occurs after Excising the Turn of the Folding-Nucleating Hairpin.,Kier BL, Anderson JM, Andersen NH J Am Chem Soc. 2014 Jan 3. PMID:24350581<ref>PMID:24350581</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mdu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kier, B L]]
[[Category: Kier BL]]
[[Category: Circular permutation]]
[[Category: Dynamic]]
[[Category: Folding]]
[[Category: Isomerase]]
[[Category: Miniprotein]]

Latest revision as of 06:59, 1 May 2024

Circular Permutant of the WW Domain with Loop 1 Excised

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