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==AIK-18/51 DNA recognition sequence d(CGACTAGTCG)2==
==AIK-18/51 DNA recognition sequence d(CGACTAGTCG)2==
<StructureSection load='2mnf' size='340' side='right' caption='[[2mnf]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2mnf' size='340' side='right'caption='[[2mnf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mnf]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MNF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mnf]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MNF FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mnd|2mnd]], [[2mne|2mne]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mnf RCSB], [http://www.ebi.ac.uk/pdbsum/2mnf PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mnf OCA], [https://pdbe.org/2mnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mnf RCSB], [https://www.ebi.ac.uk/pdbsum/2mnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mnf ProSAT]</span></td></tr>
<table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Solution-phase self-association characteristics and DNA molecular-recognition properties are reported for three close analogues of minor-groove-binding ligands from the thiazotropsin class of lexitropsin molecules; they incorporate isopropyl thiazole as a lipophilic building block. Thiazotropsin B (AcImPyiPr ThDp) shows similar self-assembly characteristics to thiazotropsin A (FoPyPyiPr ThDp), although it is engineered, by incorporation of imidazole in place of N-methyl pyrrole, to swap its DNA recognition target from 5'-ACTAGT-3' to 5'-ACGCGT-3'. Replacement of the formamide head group in thiazotropsin A by nicotinamide in AIK-18/51 results in a measureable difference in solution-phase self-assembly character and substantially enhanced DNA association characteristics. The structures and associated thermodynamic parameters of self-assembled ligand aggregates and their complexes with their respective DNA targets are considered in the context of cluster targeting of DNA by minor-groove complexes.
 
Recognition of the DNA Minor Groove by Thiazotropsin Analogues.,Alniss HY, Salvia MV, Sadikov M, Golovchenko I, Anthony NG, Khalaf AI, MacKay SP, Suckling CJ, Parkinson JA Chembiochem. 2014 Jul 16. doi: 10.1002/cbic.201402202. PMID:25045155<ref>PMID:25045155</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alniss, H Y.]]
[[Category: Large Structures]]
[[Category: Anthony, N G.]]
[[Category: Alniss HY]]
[[Category: Golovchenko, I.]]
[[Category: Anthony NG]]
[[Category: Khalaf, A I.]]
[[Category: Golovchenko I]]
[[Category: Mackay, S P.]]
[[Category: Khalaf AI]]
[[Category: Parkinson, J A.]]
[[Category: Mackay SP]]
[[Category: Sadikov, M.]]
[[Category: Parkinson JA]]
[[Category: Salvia, M V.]]
[[Category: Sadikov M]]
[[Category: Suckling, C J.]]
[[Category: Salvia M-V]]
[[Category: Dna]]
[[Category: Suckling CJ]]
[[Category: Dna recognition]]
[[Category: Isothermal titration calorimetry nmr]]
[[Category: Minor groove binder]]
[[Category: Self-assembly]]
[[Category: Thiazotropsin]]

Latest revision as of 07:01, 1 May 2024

AIK-18/51 DNA recognition sequence d(CGACTAGTCG)2

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