2rr6: Difference between revisions
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==Solution structure of the leucine rich repeat of human acidic leucine-rich nuclear phosphoprotein 32 family member B== | |||
<StructureSection load='2rr6' size='340' side='right'caption='[[2rr6]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2rr6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RR6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rr6 OCA], [https://pdbe.org/2rr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rr6 RCSB], [https://www.ebi.ac.uk/pdbsum/2rr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rr6 ProSAT]</span></td></tr> | |||
== | </table> | ||
[[2rr6]] is a 1 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/AN32B_HUMAN AN32B_HUMAN] Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.<ref>PMID:20538007</ref> | |||
== | == Evolutionary Conservation == | ||
< | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rr/2rr6_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rr6 ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Harada | [[Category: Large Structures]] | ||
[[Category: Kigawa | [[Category: Harada T]] | ||
[[Category: Koshiba | [[Category: Kigawa T]] | ||
[[Category: Tanaka | [[Category: Koshiba S]] | ||
[[Category: Tochio | [[Category: Tanaka A]] | ||
[[Category: Tsuda | [[Category: Tochio N]] | ||
[[Category: Umehara | [[Category: Tsuda K]] | ||
[[Category: Watanabe | [[Category: Umehara T]] | ||
[[Category: Yokoyama | [[Category: Watanabe S]] | ||
[[Category: Yokoyama S]] | |||
Latest revision as of 07:06, 1 May 2024
Solution structure of the leucine rich repeat of human acidic leucine-rich nuclear phosphoprotein 32 family member B
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