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[[Image:4aif.jpg|left|200px]]


{{STRUCTURE_4aif|  PDB=4aif  |  SCENE=  }}
==AIP TPR domain in complex with human Hsp90 peptide==
 
<StructureSection load='4aif' size='340' side='right'caption='[[4aif]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
===AIP TPR domain in complex with human Hsp90 peptide===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4aif]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AIF FirstGlance]. <br>
{{ABSTRACT_PUBMED_23300914}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.006&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aif OCA], [https://pdbe.org/4aif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aif RCSB], [https://www.ebi.ac.uk/pdbsum/4aif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aif ProSAT]</span></td></tr>
[[4aif]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIF OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/AIP_HUMAN AIP_HUMAN] Acromegaly;Familial prolactinoma. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA) [MIM:[https://omim.org/entry/102200 102200]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma.<ref>PMID:17244780</ref> <ref>PMID:17299063</ref> <ref>PMID:17360484</ref> <ref>PMID:18410548</ref>  Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA) [MIM:[https://omim.org/entry/219090 219090]; also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.  Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA) [MIM:[https://omim.org/entry/600634 600634]; also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.
== Function ==
[https://www.uniprot.org/uniprot/AIP_HUMAN AIP_HUMAN] May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.  Cellular negative regulator of the hepatitis B virus (HBV) X protein.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Morgan, R M.L.]]
[[Category: Large Structures]]
[[Category: Pearl, L H.]]
[[Category: Morgan RML]]
[[Category: Prodromou, C.]]
[[Category: Pearl LH]]
[[Category: Roe, S M.]]
[[Category: Prodromou C]]
[[Category: Aryl hydrocarbon receptor]]
[[Category: Roe SM]]
[[Category: Signaling protein-peptide complex]]
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