6ob1: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 6ob1 is ~~ON HOLD~~

==Structure of WHB in complex with Ubiquitin Variant==

== Structural highlights ==

<table><tr><td colspan='2'>[[6ob1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OB1 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ob1 OCA], [https://pdbe.org/6ob1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ob1 RCSB], [https://www.ebi.ac.uk/pdbsum/6ob1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ob1 ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ANC2_HUMAN ANC2_HUMAN] Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.<ref>PMID:11739784</ref> <ref>PMID:18485873</ref>

~~Authors~~:

==See Also==

*[[3D structures of ubiquitin|3D structures of ubiquitin]]

~~Description~~:

== References ==

[[Category: ~~Unreleased Structures~~]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Edmond RW]]

[[Category: Grace CR]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ob1 is ON HOLD
+==Structure of WHB in complex with Ubiquitin Variant==
+<StructureSection load='6ob1' size='340' side='right'caption='[[6ob1]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ob1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OB1 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ob1 OCA], [https://pdbe.org/6ob1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ob1 RCSB], [https://www.ebi.ac.uk/pdbsum/6ob1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ob1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ANC2_HUMAN ANC2_HUMAN] Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.<ref>PMID:11739784</ref> <ref>PMID:18485873</ref>
-Authors:
+==See Also==
+*[[3D structures of ubiquitin|3D structures of ubiquitin]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Edmond RW]]
+[[Category: Grace CR]]