7cnf: Difference between revisions
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==Solution strcture of HsTFIIS LW domain== | |||
<StructureSection load='7cnf' size='340' side='right'caption='[[7cnf]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7cnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CNF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cnf OCA], [https://pdbe.org/7cnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cnf RCSB], [https://www.ebi.ac.uk/pdbsum/7cnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cnf ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gao J]] | |||
[[Category: Liao S]] | |||
Latest revision as of 07:48, 1 May 2024
Solution strcture of HsTFIIS LW domain
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