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[[Image:1tm0.gif|left|200px]]


{{Structure
==Crystal Structure of the putative proline racemase from Brucella melitensis, Northeast Structural Genomics Target LR31==
|PDB= 1tm0 |SIZE=350|CAPTION= <scene name='initialview01'>1tm0</scene>, resolution 2.8&Aring;
<StructureSection load='1tm0' size='340' side='right'caption='[[1tm0]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[1tm0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_melitensis_bv._1_str._16M Brucella melitensis bv. 1 str. 16M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TM0 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm0 OCA], [https://pdbe.org/1tm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tm0 RCSB], [https://www.ebi.ac.uk/pdbsum/1tm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tm0 ProSAT], [https://www.topsan.org/Proteins/NESGC/1tm0 TOPSAN]</span></td></tr>
 
</table>
'''Crystal Structure of the putative proline racemase from Brucella melitensis, Northeast Structural Genomics Target LR31'''
== Function ==
 
[https://www.uniprot.org/uniprot/Y1586_BRUME Y1586_BRUME] In vitro, catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp) and that of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp), albeit with very low efficiency. The physiological substrate may be different (PubMed:24980702). Displays neither proline racemase activity nor t3LHyp dehydratase activity (PubMed:17849014, PubMed:24980702).<ref>PMID:17849014</ref> <ref>PMID:24980702</ref> <ref>PMID:24980702</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1TM0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brucella_melitensis_16m Brucella melitensis 16m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM0 OCA].  
Check<jmol>
[[Category: Brucella melitensis 16m]]
  <jmolCheckbox>
[[Category: Proline racemase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tm0_consurf.spt"</scriptWhenChecked>
[[Category: Single protein]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Acton, T B.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Chen, Y.]]
  </jmolCheckbox>
[[Category: Cooper, B.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tm0 ConSurf].
[[Category: Forouhar, F.]]
<div style="clear:both"></div>
[[Category: Ho, C K.]]
== References ==
[[Category: Hunt, J F.]]
<references/>
[[Category: Ma, L C.]]
__TOC__
[[Category: Montelione, G T.]]
</StructureSection>
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Brucella melitensis bv. 1 str. 16M]]
[[Category: Tong, L.]]
[[Category: Large Structures]]
[[Category: Xiao, R.]]
[[Category: Acton TB]]
[[Category: alpha-beta protein that resembles double-beta barrel]]
[[Category: Chen Y]]
[[Category: in each of which an alpha helix is sandwiched]]
[[Category: Cooper B]]
[[Category: nesg]]
[[Category: Forouhar F]]
[[Category: northeast structural genomics consortium]]
[[Category: Ho CK]]
[[Category: protein structure initiative]]
[[Category: Hunt JF]]
[[Category: psi]]
[[Category: Ma L-C]]
[[Category: structural genomic]]
[[Category: Montelione GT]]
 
[[Category: Tong L]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:20:10 2008''
[[Category: Xiao R]]
Retrieved from "https://proteopedia.org/1tm0"