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==Solution Structure of apo GroEL by Cryo-Electron microscopy==
==Solution Structure of apo GroEL by Cryo-Electron microscopy==
<StructureSection load='1gr5' size='340' side='right' caption='[[1gr5]], [[Resolution|resolution]] 7.90&Aring;' scene=''>
<SX load='1gr5' size='340' side='right' viewer='molstar' caption='[[1gr5]], [[Resolution|resolution]] 7.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1gr5]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GR5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1gr5]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GR5 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aon|1aon]], [[1der|1der]], [[1fy9|1fy9]], [[1fya|1fya]], [[1grl|1grl]], [[1jon|1jon]], [[1kid|1kid]], [[1oel|1oel]], [[2c7e|2c7e]], [[1gru|1gru]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gr5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gr5 RCSB], [http://www.ebi.ac.uk/pdbsum/1gr5 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gr5 OCA], [https://pdbe.org/1gr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gr5 RCSB], [https://www.ebi.ac.uk/pdbsum/1gr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gr5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CH60_ECOL6 CH60_ECOL6]] Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity).  
[https://www.uniprot.org/uniprot/CH60_ECOLI CH60_ECOLI] Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.[HAMAP-Rule:MF_00600]  Essential for the growth of the bacteria and the assembly of several bacteriophages. Also plays a role in coupling between replication of the F plasmid and cell division of the cell.[HAMAP-Rule:MF_00600]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/1gr5_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/1gr5_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gr5 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1gr5" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Chaperonin|Chaperonin]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
*[[Heat Shock Proteins|Heat Shock Proteins]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Farr, G W]]
[[Category: Large Structures]]
[[Category: Fenton, W A]]
[[Category: Farr GW]]
[[Category: Gowen, B]]
[[Category: Fenton WA]]
[[Category: Horwich, A L]]
[[Category: Gowen B]]
[[Category: Ranson, N A]]
[[Category: Horwich AL]]
[[Category: Roseman, A M]]
[[Category: Ranson NA]]
[[Category: Saibil, H R]]
[[Category: Roseman AM]]
[[Category: Chaperone]]
[[Category: Saibil HR]]

Latest revision as of 08:50, 9 May 2024

Solution Structure of apo GroEL by Cryo-Electron microscopy

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