1of5: Difference between revisions

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{{Seed}}
[[Image:1of5.png|left|200px]]


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==Crystal structure of Mex67-Mtr2==
The line below this paragraph, containing "STRUCTURE_1of5", creates the "Structure Box" on the page.
<StructureSection load='1of5' size='340' side='right'caption='[[1of5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1of5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OF5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
{{STRUCTURE_1of5|  PDB=1of5  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1of5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1of5 OCA], [https://pdbe.org/1of5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1of5 RCSB], [https://www.ebi.ac.uk/pdbsum/1of5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1of5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MEX67_YEAST MEX67_YEAST] Involved in the export of mRNA from the nucleus to the cytoplasm.<ref>PMID:9214641</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/1of5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1of5 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The association between Mtr2 and Mex67 is essential for the nuclear export of bulk messenger RNA in yeast. In metazoans, the analogous function is carried out by the TAP-p15 heterodimer. Whereas Mex67 and TAP are highly conserved proteins, their binding partners, Mtr2 and p15, share no sequence similarity, but are nevertheless functionally homologous. Here, we report the 2.8-A resolution crystal structure of Mtr2 in complex with the NTF2-like domain of Mex67. Mtr2 is a novel member of the NTF2-like family and interacts with Mex67, forming a complex with a similar structural architecture to that of TAP-p15. Mtr2 fulfils an analogous function to that of human p15 in maintaining the structural integrity of the heterodimer. In addition, Mtr2 presents a long internal loop, which contains residues that affect the export of the large ribosomal subunit.


===CRYSTAL STRUCTURE OF MEX67-MTR2===
Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15.,Fribourg S, Conti E EMBO Rep. 2003 Jul;4(7):699-703. PMID:12835756<ref>PMID:12835756</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 12835756 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_12835756}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1OF5 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OF5 OCA].
 
==Reference==
<ref group="xtra">PMID:12835756</ref><references group="xtra"/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Conti, E.]]
[[Category: Conti E]]
[[Category: Fribourg, S.]]
[[Category: Fribourg S]]
[[Category: Leucine-rich repeat]]
[[Category: Mrna transport]]
[[Category: Nuclear protein]]
[[Category: Nuclear transport]]
[[Category: Repeat]]
[[Category: Transport]]
 
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Retrieved from "https://proteopedia.org/1of5"