2izy: Difference between revisions

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{{Seed}}
[[Image:2izy.png|left|200px]]


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==Molecular Basis of AKAP Specificity for PKA Regulatory Subunits==
The line below this paragraph, containing "STRUCTURE_2izy", creates the "Structure Box" on the page.
<StructureSection load='2izy' size='340' side='right'caption='[[2izy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2izy]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZY FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izy OCA], [https://pdbe.org/2izy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izy RCSB], [https://www.ebi.ac.uk/pdbsum/2izy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izy ProSAT]</span></td></tr>
{{STRUCTURE_2izy|  PDB=2izy  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAP2_MOUSE KAP2_MOUSE] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/2izy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2izy ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Localization of cyclic AMP (cAMP)-dependent protein kinase (PKA) by A kinase-anchoring proteins (AKAPs) restricts the action of this broad specificity kinase. The high-resolution crystal structures of the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA both in the apo state and in complex with the high-affinity anchoring peptide AKAP-IS explain the molecular basis for AKAP-regulatory subunit recognition. AKAP-IS folds into an amphipathic alpha helix that engages an essentially preformed shallow groove on the surface of the RII dimer D/D domains. Conserved AKAP aliphatic residues dominate interactions to RII at the predominantly hydrophobic interface, whereas polar residues are important in conferring R subunit isoform specificity. Using a peptide screening approach, we have developed SuperAKAP-IS, a peptide that is 10,000-fold more selective for the RII isoform relative to RI and can be used to assess the impact of PKA isoform-selective anchoring on cAMP-responsive events inside cells.


===MOLECULAR BASIS OF AKAP SPECIFICITY FOR PKA REGULATORY SUBUNITS===
Molecular basis of AKAP specificity for PKA regulatory subunits.,Gold MG, Lygren B, Dokurno P, Hoshi N, McConnachie G, Tasken K, Carlson CR, Scott JD, Barford D Mol Cell. 2006 Nov 3;24(3):383-95. PMID:17081989<ref>PMID:17081989</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2izy" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_17081989}}, adds the Publication Abstract to the page
*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 17081989 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17081989}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2IZY is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZY OCA].
 
==Reference==
<ref group="xtra">PMID:17081989</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: CAMP-dependent protein kinase]]
[[Category: Barford D]]
[[Category: Barford, D.]]
[[Category: Carlson CR]]
[[Category: Carlson, C R.]]
[[Category: Dokurno P]]
[[Category: Dokurno, P.]]
[[Category: Gold MG]]
[[Category: Gold, M G.]]
[[Category: Hoshi N]]
[[Category: Hoshi, N.]]
[[Category: Lygren B]]
[[Category: Lygren, B.]]
[[Category: McConnachie G]]
[[Category: Mcconnachie, G.]]
[[Category: Scott JD]]
[[Category: Scott, J D.]]
[[Category: Tasken K]]
[[Category: Tasken, K.]]
[[Category: Acetylation]]
[[Category: Camp]]
[[Category: Camp-binding]]
[[Category: D/d]]
[[Category: Kinase]]
[[Category: Nucleotide-binding]]
[[Category: Phosphorylation]]
[[Category: Pka]]
[[Category: Rii]]
[[Category: Transferase]]
 
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Retrieved from "https://proteopedia.org/2izy"