2kt0: Difference between revisions

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{{Seed}}
[[Image:2kt0.png|left|200px]]


<!--
==Solution structure of human stem cell transcription factor Nanog homeodomain fragment==
The line below this paragraph, containing "STRUCTURE_2kt0", creates the "Structure Box" on the page.
<StructureSection load='2kt0' size='340' side='right'caption='[[2kt0]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kt0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KT0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kt0 OCA], [https://pdbe.org/2kt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kt0 RCSB], [https://www.ebi.ac.uk/pdbsum/2kt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kt0 ProSAT]</span></td></tr>
{{STRUCTURE_2kt0|  PDB=2kt0  |  SCENE=  }}
</table>
 
== Function ==
===Solution structure of human stem cell transcription factor Nanog homeodomain fragment===
[https://www.uniprot.org/uniprot/NANOG_HUMAN NANOG_HUMAN] Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.<ref>PMID:15983365</ref> <ref>PMID:16000880</ref> <ref>PMID:16391521</ref> <ref>PMID:25825768</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2KT0 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT0 OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/2kt0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kt0 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Large Structures]]
[[Category: Markley, J L.]]
[[Category: Markley JL]]
[[Category: Sahu, S C.]]
[[Category: Sahu SC]]
[[Category: Center for eukaryotic structural genomic]]
[[Category: Cesg]]
[[Category: Dna-binding]]
[[Category: Homeobox]]
[[Category: Homeodomain]]
[[Category: Nanog]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Stem cell]]
[[Category: Structural genomic]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  3 14:20:02 2010''
Retrieved from "https://proteopedia.org/2kt0"