2uwj: Difference between revisions

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==STRUCTURE OF THE HETEROTRIMERIC COMPLEX WHICH REGULATES TYPE III SECRETION NEEDLE FORMATION==
 
<StructureSection load='2uwj' size='340' side='right' caption='[[2uwj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
==Structure of the heterotrimeric complex which regulates type III secretion needle formation==
<StructureSection load='2uwj' size='340' side='right'caption='[[2uwj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2uwj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2uwj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_CHA Pseudomonas aeruginosa CHA]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwj OCA], [http://pdbe.org/2uwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwj RCSB], [http://www.ebi.ac.uk/pdbsum/2uwj PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwj OCA], [https://pdbe.org/2uwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwj RCSB], [https://www.ebi.ac.uk/pdbsum/2uwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PSCG_PSEAE PSCG_PSEAE]] Prevents premature polymerization of PscF, along with PscE, within the cytoplasm. Required for type III secretion needle assembly. Also required for cytotoxicity by influencing PscF levels. [[http://www.uniprot.org/uniprot/PSCF_PSEAE PSCF_PSEAE]] Major component of the type III secretion needle structure. Required for cytotoxicity on macrophages.<ref>PMID:16239085</ref> <ref>PMID:16115870</ref>
[https://www.uniprot.org/uniprot/PSCF_PSEAE PSCF_PSEAE] Major component of the type III secretion needle structure. Required for cytotoxicity on macrophages.<ref>PMID:16239085</ref> <ref>PMID:16115870</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwj_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwj_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Attree, I]]
[[Category: Large Structures]]
[[Category: Contreras-Martel, C]]
[[Category: Pseudomonas aeruginosa CHA]]
[[Category: Dessen, A]]
[[Category: Attree I]]
[[Category: Job, V]]
[[Category: Contreras-Martel C]]
[[Category: Ple, S]]
[[Category: Dessen A]]
[[Category: Quinaud, M]]
[[Category: Job V]]
[[Category: Simorre, J P]]
[[Category: Ple S]]
[[Category: Bacterial pathogenicity]]
[[Category: Quinaud M]]
[[Category: Chaperone]]
[[Category: Simorre JP]]
[[Category: Needle formation]]
[[Category: Type iii secretion]]
[[Category: Virulence]]
Retrieved from "https://proteopedia.org/2uwj"