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==CRYSTAL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASE DOMAIN OF HUMAN STEAP3, THE DOMINANT FERRIC REDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLE==
 
<StructureSection load='2vns' size='340' side='right' caption='[[2vns]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
==Crystal Structure of the Membrane Proximal Oxidoreductase Domain of Human Steap3, the Dominant Ferric Reductase of the Erythroid Transferrin Cycle==
<StructureSection load='2vns' size='340' side='right'caption='[[2vns]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vns]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNS FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vns]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vq3|2vq3]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diferric-transferrin_reductase Diferric-transferrin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.1.2 1.16.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vns OCA], [https://pdbe.org/2vns PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vns RCSB], [https://www.ebi.ac.uk/pdbsum/2vns PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vns ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vns OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vns RCSB], [http://www.ebi.ac.uk/pdbsum/2vns PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/STEA3_HUMAN STEA3_HUMAN]] Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.<ref>PMID:12866033</ref> <ref>PMID:15319436</ref> <ref>PMID:16651434</ref>
[https://www.uniprot.org/uniprot/STEA3_HUMAN STEA3_HUMAN] Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.<ref>PMID:12866033</ref> <ref>PMID:15319436</ref> <ref>PMID:16651434</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vns_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vns_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vns ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2vns" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Diferric-transferrin reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fleming, M D]]
[[Category: Large Structures]]
[[Category: Lawrence, C M]]
[[Category: Fleming MD]]
[[Category: Ohgami, R S]]
[[Category: Lawrence CM]]
[[Category: Sendamarai, A K]]
[[Category: Ohgami RS]]
[[Category: Apoptosis]]
[[Category: Sendamarai AK]]
[[Category: Cell cycle]]
[[Category: Dinucleotide-binding domain]]
[[Category: Endosome]]
[[Category: Fad]]
[[Category: Ferric-reductase]]
[[Category: Ferrireductase]]
[[Category: Flavoprotein]]
[[Category: Fno]]
[[Category: Glycoprotein]]
[[Category: Ion transport]]
[[Category: Iron]]
[[Category: Iron transport]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Nad]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Phosphoprotein]]
[[Category: Rossmann fold]]
[[Category: Steap]]
[[Category: Steap3]]
[[Category: Tf]]
[[Category: Tfr]]
[[Category: Tfr1]]
[[Category: Transferrin]]
[[Category: Transferrin receptor]]
[[Category: Transmembrane]]
[[Category: Transport]]
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