4b03: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (7 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
== | ==6A Electron cryomicroscopy structure of immature Dengue virus serotype 1== | ||
[[http://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV | <SX load='4b03' size='340' side='right' viewer='molstar' caption='[[4b03]], [[Resolution|resolution]] 6.00Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4b03]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B03 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b03 OCA], [https://pdbe.org/4b03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b03 RCSB], [https://www.ebi.ac.uk/pdbsum/4b03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b03 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-A resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation. | |||
Immature and mature dengue serotype 1 virus structures provide insight into the maturation process.,Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM J Virol. 2013 Jul;87(13):7700-7. doi: 10.1128/JVI.00197-13. Epub 2013 May 1. PMID:23637416<ref>PMID:23637416</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
< | </div> | ||
<div class="pdbe-citations 4b03" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</SX> | |||
[[Category: Dengue virus 1]] | [[Category: Dengue virus 1]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Kostyuchenko VA]] | ||
[[Category: | [[Category: Lok SM]] | ||
[[Category: | [[Category: Ng TS]] | ||
[[Category: | [[Category: Tan LC]] | ||
[[Category: | [[Category: Zhang Q]] | ||
Latest revision as of 10:55, 9 May 2024
6A Electron cryomicroscopy structure of immature Dengue virus serotype 1
| ||||||||
