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==Crystal structure of Escherichia coli 23S rRNA (A2030-N6)- methyltransferase RlmJ==
==Crystal structure of Escherichia coli 23S rRNA (A2030-N6)- methyltransferase RlmJ==
<StructureSection load='4blu' size='340' side='right' caption='[[4blu]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4blu' size='340' side='right'caption='[[4blu]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4blu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4blu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BLU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4blv|4blv]], [[4blw|4blw]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/23S_rRNA_(adenine(2030)-N(6))-methyltransferase 23S rRNA (adenine(2030)-N(6))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.266 2.1.1.266] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4blu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blu OCA], [https://pdbe.org/4blu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4blu RCSB], [https://www.ebi.ac.uk/pdbsum/4blu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4blu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4blu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4blu OCA], [http://pdbe.org/4blu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4blu RCSB], [http://www.ebi.ac.uk/pdbsum/4blu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4blu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RLMJ_ECOLI RLMJ_ECOLI]] Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necessary for ribosome assembly. Seems to be required for the utilization of extracellular DNA as the sole source of carbon and energy.<ref>PMID:16707682</ref> <ref>PMID:22847818</ref>
[https://www.uniprot.org/uniprot/RLMJ_ECOLI RLMJ_ECOLI] Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necessary for ribosome assembly. Seems to be required for the utilization of extracellular DNA as the sole source of carbon and energy.<ref>PMID:16707682</ref> <ref>PMID:22847818</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Forster, A C]]
[[Category: Large Structures]]
[[Category: Liljeruhm, J]]
[[Category: Forster AC]]
[[Category: Punekar, A S]]
[[Category: Liljeruhm J]]
[[Category: Selmer, M]]
[[Category: Punekar AS]]
[[Category: Shepherd, T R]]
[[Category: Selmer M]]
[[Category: N6-methyladenine]]
[[Category: Shepherd TR]]
[[Category: Rossmann-like fold]]
[[Category: Subdomain insertion]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4blu"