4bne: Difference between revisions
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==Pacsin2 Interacts with Membranes and Actin-Filaments== | ==Pacsin2 Interacts with Membranes and Actin-Filaments== | ||
<StructureSection load='4bne' size='340' side='right' caption='[[4bne]], [[Resolution|resolution]] 2.57Å' scene=''> | <StructureSection load='4bne' size='340' side='right'caption='[[4bne]], [[Resolution|resolution]] 2.57Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BNE OCA]. <br> | <table><tr><td colspan='2'>[[4bne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BNE FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57Å</td></tr> | ||
<tr><td class="sblockLbl"><b> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bne OCA], [https://pdbe.org/4bne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bne RCSB], [https://www.ebi.ac.uk/pdbsum/4bne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bne ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PACN2_CHICK PACN2_CHICK] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Two mechanisms have emerged as major regulators of membrane shape: BAR domain-containing proteins, which induce invaginations and protrusions, and nuclear promoting factors, which cause generation of branched actin filaments that exert mechanical forces on membranes. While a large body of information exists on interactions of BAR proteins with membranes and regulatory proteins of the cytoskeleton, little is known about connections between these two processes. Here, we show that the F-BAR domain protein pacsin2 is able to associate with actin filaments using the same concave surface employed to bind to membranes, while some other tested N-BAR and F-BAR proteins (endophilin, CIP4 and FCHO2) do not associate with actin. This finding reveals a new level of complexity in membrane remodeling processes. | |||
Direct interaction of actin filaments with F-BAR protein pacsin2.,Kostan J, Salzer U, Orlova A, Toro I, Hodnik V, Senju Y, Zou J, Schreiner C, Steiner J, Merilainen J, Nikki M, Virtanen I, Carugo O, Rappsilber J, Lappalainen P, Lehto VP, Anderluh G, Egelman EH, Djinovic-Carugo K EMBO Rep. 2014 Sep 12. pii: e201439267. PMID:25216944<ref>PMID:25216944</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4bne" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Anderluh | [[Category: Gallus gallus]] | ||
[[Category: Djinovic-Carugo | [[Category: Large Structures]] | ||
[[Category: Egelman | [[Category: Anderluh G]] | ||
[[Category: Hodnik | [[Category: Djinovic-Carugo K]] | ||
[[Category: Kostan | [[Category: Egelman EH]] | ||
[[Category: Lehto | [[Category: Hodnik V]] | ||
[[Category: Merilainen | [[Category: Kostan J]] | ||
[[Category: Nikki | [[Category: Lehto V-P]] | ||
[[Category: Orlova | [[Category: Merilainen J]] | ||
[[Category: Salzer | [[Category: Nikki M]] | ||
[[Category: Schreiner | [[Category: Orlova A]] | ||
[[Category: Toeroe | [[Category: Salzer U]] | ||
[[Category: Virtanen | [[Category: Schreiner C]] | ||
[[Category: Toeroe I]] | |||
[[Category: Virtanen I]] | |||
Latest revision as of 11:02, 9 May 2024
Pacsin2 Interacts with Membranes and Actin-Filaments
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