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==Crystal structure of Chaetomium thermophilum Raptor==
==Crystal structure of Chaetomium thermophilum Raptor==
<StructureSection load='5ef5' size='340' side='right' caption='[[5ef5]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
<StructureSection load='5ef5' size='340' side='right'caption='[[5ef5]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ef5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EF5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ef5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EF5 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ef5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ef5 OCA], [http://pdbe.org/5ef5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ef5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ef5 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ef5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ef5 OCA], [https://pdbe.org/5ef5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ef5 RCSB], [https://www.ebi.ac.uk/pdbsum/5ef5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ef5 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Target of rapamycin (TOR), a conserved protein kinase and central controller of cell growth, functions in two structurally and functionally distinct complexes: TORC1 and TORC2. Dysregulation of mammalian TOR (mTOR) signaling is implicated in pathologies that include diabetes, cancer, and neurodegeneration. We resolved the architecture of human mTORC1 (mTOR with subunits Raptor and mLST8) bound to FK506 binding protein (FKBP)-rapamycin, by combining cryo-electron microscopy at 5.9 angstrom resolution with crystallographic studies of Chaetomium thermophilum Raptor at 4.3 angstrom resolution. The structure explains how FKBP-rapamycin and architectural elements of mTORC1 limit access to the recessed active site. Consistent with a role in substrate recognition and delivery, the conserved amino-terminal domain of Raptor is juxtaposed to the kinase active site.
Architecture of human mTOR complex 1.,Aylett CH, Sauer E, Imseng S, Boehringer D, Hall MN, Ban N, Maier T Science. 2016 Jan 1;351(6268):48-52. doi: 10.1126/science.aaa3870. Epub 2015 Dec , 17. PMID:26678875<ref>PMID:26678875</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ef5" style="background-color:#fffaf0;"></div>
==See Also==
*[[Raptor 3D structures|Raptor 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aylett, C H.S]]
[[Category: Chaetomium thermophilum]]
[[Category: Ban, N]]
[[Category: Large Structures]]
[[Category: Boehringer, D]]
[[Category: Aylett CHS]]
[[Category: Hall, M N]]
[[Category: Ban N]]
[[Category: Imseng, S]]
[[Category: Boehringer D]]
[[Category: Maier, T]]
[[Category: Hall MN]]
[[Category: Sauer, E]]
[[Category: Imseng S]]
[[Category: Mtorc1]]
[[Category: Maier T]]
[[Category: Raptor]]
[[Category: Sauer E]]
[[Category: Rptor]]
[[Category: Signaling protein]]
[[Category: Target of rapamycin]]
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