6f45: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: '''Unreleased structure''' The entry 6f45 is ON HOLD until Paper Publication Authors: Dunne, M., Leiman, P., Klumpp, J., Loessner, M.J. Description: Crystal structure of the gp37-gp38 ...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 6f45 is ON HOLD  until Paper Publication
==Crystal structure of the gp37-gp38 adhesin tip complex of the bacteriophage S16 long tail fiber==
<StructureSection load='6f45' size='340' side='right'caption='[[6f45]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6f45]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_phage_vB_SenM-S16 Salmonella phage vB_SenM-S16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F45 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7035582&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f45 OCA], [https://pdbe.org/6f45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f45 RCSB], [https://www.ebi.ac.uk/pdbsum/6f45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f45 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M1EBB2_BPS16 M1EBB2_BPS16] Vg38 is at the tip of the long tail fibers and serves as the phage recognition site for the cellular receptor.[ARBA:ARBA00003549]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The ability of phages to infect specific bacteria has led to their exploitation as bio-tools for bacterial remediation and detection. Many phages recognize bacterial hosts via adhesin tips of their long tail fibers (LTFs). Adhesin sequence plasticity modulates receptor specificity, and thus primarily defines a phage's host range. Here we present the crystal structure of an adhesin (gp38) attached to a trimeric beta-helical tip (gp37) from the Salmonella phage S16 LTF. Gp38 contains rare polyglycine type II helices folded into a packed lattice, herein designated "PGII sandwich." Sequence variability within the domain is limited to surface-exposed helices and distal loops that form putative receptor-binding sites. In silico analyses revealed a prevalence of the adhesin architecture among T-even phages, excluding the archetypal T4 phage. Overall, S16 LTF provides a valuable model for understanding binding mechanisms of phage adhesins, and for engineering of phage adhesins with expandable or modulated host ranges.


Authors: Dunne, M., Leiman, P., Klumpp, J., Loessner, M.J.
Salmonella Phage S16 Tail Fiber Adhesin Features a Rare Polyglycine Rich Domain for Host Recognition.,Dunne M, Denyes JM, Arndt H, Loessner MJ, Leiman PG, Klumpp J Structure. 2018 Aug 16. pii: S0969-2126(18)30263-6. doi:, 10.1016/j.str.2018.07.017. PMID:30244968<ref>PMID:30244968</ref>


Description: Crystal structure of the gp37-gp38 adhesin tip complex of the bacteriophage S16 long tail fiber
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Dunne, M]]
<div class="pdbe-citations 6f45" style="background-color:#fffaf0;"></div>
[[Category: Klumpp, J]]
== References ==
[[Category: Loessner, M.J]]
<references/>
[[Category: Leiman, P]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella phage vB_SenM-S16]]
[[Category: Dunne M]]
[[Category: Klumpp J]]
[[Category: Leiman P]]
[[Category: Loessner MJ]]
Retrieved from "https://proteopedia.org/6f45"