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New page: left|200px<br /> <applet load="1wfv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wfv" /> '''Solution structure of the fifth PDZ domain ...
 
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[[Image:1wfv.gif|left|200px]]<br />
<applet load="1wfv" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1wfv" />
'''Solution structure of the fifth PDZ domain of human membrane associated guanylate kinase inverted-2 (KIAA0705 protein)'''<br />


==About this Structure==
==Solution structure of the fifth PDZ domain of human membrane associated guanylate kinase inverted-2 (KIAA0705 protein)==
1WFV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WFV OCA].  
<StructureSection load='1wfv' size='340' side='right'caption='[[1wfv]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1wfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WFV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfv OCA], [https://pdbe.org/1wfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wfv RCSB], [https://www.ebi.ac.uk/pdbsum/1wfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wfv ProSAT], [https://www.topsan.org/Proteins/RSGI/1wfv TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAGI2_HUMAN MAGI2_HUMAN] Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.<ref>PMID:10760291</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/1wfv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wfv ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Tochio N]]
[[Category: Tochio, N.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: activin receptor interacting protein 1]]
[[Category: activin type iia receptor]]
[[Category: actriia]]
[[Category: acvrip1]]
[[Category: aip1]]
[[Category: arip1]]
[[Category: atrophin-1 interacting protein 1]]
[[Category: magi-2]]
[[Category: membrane associated guanylate kinase inverted-2]]
[[Category: pdz domain]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
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Retrieved from "https://proteopedia.org/1wfv"