2c5z: Difference between revisions

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==STRUCTURE AND CTD BINDING OF THE SET2 SRI DOMAIN==
 
<StructureSection load='2c5z' size='340' side='right' caption='[[2c5z]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
==Structure and CTD binding of the Set2 SRI domain==
<StructureSection load='2c5z' size='340' side='right'caption='[[2c5z]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C5Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C5Z FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e0n|1e0n]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5z OCA], [http://pdbe.org/2c5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c5z RCSB], [http://www.ebi.ac.uk/pdbsum/2c5z PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5z OCA], [https://pdbe.org/2c5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c5z RCSB], [https://www.ebi.ac.uk/pdbsum/2c5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SET2_YEAST SET2_YEAST] Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent.<ref>PMID:11839797</ref> <ref>PMID:12629047</ref> <ref>PMID:12736296</ref> <ref>PMID:12773564</ref> <ref>PMID:12917322</ref> <ref>PMID:15798214</ref> <ref>PMID:16227595</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/2c5z_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/2c5z_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c5z ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Cramer, P]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Sattler, M]]
[[Category: Cramer P]]
[[Category: Simon, B]]
[[Category: Sattler M]]
[[Category: Strahl, B D]]
[[Category: Simon B]]
[[Category: Vojnic, E]]
[[Category: Strahl BD]]
[[Category: Ctd]]
[[Category: Vojnic E]]
[[Category: Rna polymerase ii]]
[[Category: Set2 histone methyltransferase]]
[[Category: Sri domain]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/2c5z"