2ld8: Difference between revisions

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[[Image:2ld8.jpg|left|200px]]


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==Structure of Human Telomeric DNA in Crowded Solution==
The line below this paragraph, containing "STRUCTURE_2ld8", creates the "Structure Box" on the page.
<StructureSection load='2ld8' size='340' side='right'caption='[[2ld8]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ld8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LD8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ld8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ld8 OCA], [https://pdbe.org/2ld8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ld8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ld8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ld8 ProSAT]</span></td></tr>
{{STRUCTURE_2ld8|  PDB=2ld8  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
G-quadruplex structures formed by DNA at the human telomeres are attractive anticancer targets. Human telomeric sequences can adopt a diverse range of intramolecular G-quadruplex conformations: a parallel-stranded conformation was observed in the crystalline state, while at least four other forms were seen in K(+) solution, raising the question of which conformation is favored in crowded cellular environment. Here, we report the first NMR structure of a human telomeric G-quadruplex in crowded solution. We show that four different G-quadruplex conformations are converted to a propeller-type parallel-stranded G-quadruplex in K(+)-containing crowded solution due to water depletion. This study also reveals the formation of a new higher-order G-quadruplex structure under molecular crowding conditions. Our molecular dynamics simulations of solvent distribution provide insights at molecular level on the formation of parallel-stranded G-quadruplex in environment depleted of water. These results regarding human telomeric DNA can be extended to oncogenic promoters and other genomic G-rich sequences.


===Structure of Human Telomeric DNA in Crowded Solution===
Structure of Human Telomeric DNA in Crowded Solution.,Heddi B, Phan AT J Am Chem Soc. 2011 Jun 29;133(25):9824-9833. Epub 2011 Jun 6. PMID:21548653<ref>PMID:21548653</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_21548653}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2ld8" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 21548653 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21548653}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[2ld8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD8 OCA].
[[Category: Heddi B]]
 
[[Category: Phan AT]]
==Reference==
<ref group="xtra">PMID:021548653</ref><references group="xtra"/>
[[Category: Heddi, B.]]
[[Category: Phan, A T.]]
[[Category: Dna]]
[[Category: G-quadruplex]]
[[Category: Molecular crowding]]
[[Category: Propeller-type parallel-stranded]]
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