2le6: Difference between revisions
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==Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface== | ==Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface== | ||
<StructureSection load='2le6' size='340' side='right' caption='[[2le6 | <StructureSection load='2le6' size='340' side='right'caption='[[2le6]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
[[2le6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE6 OCA]. < | <table><tr><td colspan='2'>[[2le6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LE6 FirstGlance]. <br> | ||
<b>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<b>[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2le6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2le6 OCA], [https://pdbe.org/2le6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2le6 RCSB], [https://www.ebi.ac.uk/pdbsum/2le6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2le6 ProSAT]</span></td></tr> | ||
< | </table> | ||
<b>Resources:</b> <span class='plainlinks'>[ | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
G-rich oligonucleotides T30695 (or T30923), with the sequence of (GGGT)(4), and T40214, with the sequence of (GGGC)(4), have been reported to exhibit anti-HIV and anticancer activity. Here we report on the structure of a dimeric G-quadruplex adopted by a derivative of these sequences in K(+) solution. It comprises two identical propeller-type parallel-stranded G-quadruplex subunits each containing three G-tetrad layers that are stacked via the 5'-5' interface. We demonstrated control over the stacking of the two monomeric subunits by sequence modifications. Our analysis of possible structures at the stacking interface provides a general principle for stacking of G-quadruplexes, which could have implications for the assembly and recognition of higher-order G-quadruplex structures. | G-rich oligonucleotides T30695 (or T30923), with the sequence of (GGGT)(4), and T40214, with the sequence of (GGGC)(4), have been reported to exhibit anti-HIV and anticancer activity. Here we report on the structure of a dimeric G-quadruplex adopted by a derivative of these sequences in K(+) solution. It comprises two identical propeller-type parallel-stranded G-quadruplex subunits each containing three G-tetrad layers that are stacked via the 5'-5' interface. We demonstrated control over the stacking of the two monomeric subunits by sequence modifications. Our analysis of possible structures at the stacking interface provides a general principle for stacking of G-quadruplexes, which could have implications for the assembly and recognition of higher-order G-quadruplex structures. | ||
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Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity.,Do NQ, Lim KW, Teo MH, Heddi B, Phan AT Nucleic Acids Res. 2011 Aug 12. PMID:21840903<ref>PMID:21840903</ref> | Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity.,Do NQ, Lim KW, Teo MH, Heddi B, Phan AT Nucleic Acids Res. 2011 Aug 12. PMID:21840903<ref>PMID:21840903</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
<div class="pdbe-citations 2le6" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Do NQ]] | ||
[[Category: | [[Category: Heddi B]] | ||
[[Category: | [[Category: Lim KW]] | ||
[[Category: | [[Category: Phan AT]] | ||
[[Category: | [[Category: Teo MH]] | ||
Latest revision as of 05:42, 15 May 2024
Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface
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